diff --git a/src/libslic3r/AppConfig.cpp b/src/libslic3r/AppConfig.cpp
index e96faec66..50920a54c 100644
--- a/src/libslic3r/AppConfig.cpp
+++ b/src/libslic3r/AppConfig.cpp
@@ -482,23 +482,33 @@ std::string AppConfig::load()
     std::string error_message;
 
     try {
-        ifs.open(AppConfig::loading_path());
-
+        auto path = AppConfig::loading_path();
+        ifs.open(path);
+        if (!ifs.is_open()) {
+            BOOST_LOG_TRIVIAL(info) << "AppConfig::load() open fail:" << AppConfig::loading_path();
+            return "Line break format may be incorrect.";
+        }
 #ifdef WIN32
         std::stringstream input_stream;
         input_stream << ifs.rdbuf();
         std::string total_string = input_stream.str();
-        size_t last_pos = total_string.find_last_of('}');
-        std::string left_string = total_string.substr(0, last_pos+1);
-        //skip the "\n"
-        std::string right_string = total_string.substr(last_pos+2);
+        if (total_string.empty()) {
+            BOOST_LOG_TRIVIAL(info) << "AppConfig::load() read fail:" << AppConfig::loading_path();
+            return "read fail.";
+        } else {
+            size_t      last_pos    = total_string.find_last_of('}');
+            std::string left_string = total_string.substr(0, last_pos + 1);
+            // skip the "\n"
+            std::string right_string = total_string.substr(last_pos + 2);
 
-        std::string md5_str = appconfig_md5_hash_line({left_string.data()});
-        // Verify the checksum of the config file without taking just for debugging purpose.
-        if (md5_str != right_string)
-            BOOST_LOG_TRIVIAL(info) << "The configuration file " << AppConfig::loading_path() <<
-            " has a wrong MD5 checksum or the checksum is missing. This may indicate a file corruption or a harmless user edit.";
-        j = json::parse(left_string);
+            std::string md5_str = appconfig_md5_hash_line({left_string.data()});
+            // Verify the checksum of the config file without taking just for debugging purpose.
+            if (md5_str != right_string) {
+                BOOST_LOG_TRIVIAL(info) << "The configuration file " << AppConfig::loading_path()
+                                        << " has a wrong MD5 checksum or the checksum is missing. This may indicate a file corruption or a harmless user edit.";
+            }
+            j = json::parse(left_string);
+        }
 #else
         ifs >> j;
 #endif
diff --git a/src/libslic3r/Config.cpp b/src/libslic3r/Config.cpp
index 188a2e7ea..c9ffbff18 100644
--- a/src/libslic3r/Config.cpp
+++ b/src/libslic3r/Config.cpp
@@ -794,6 +794,10 @@ ConfigSubstitutions ConfigBase::load_from_json(const std::string &file, ForwardC
 
 int ConfigBase::load_from_json(const std::string &file, ConfigSubstitutionContext& substitution_context, bool load_inherits_to_config, std::map<std::string, std::string>& key_values, std::string& reason)
 {
+    if (!boost::filesystem::exists(file)) {
+        BOOST_LOG_TRIVIAL(error) << __FUNCTION__ << boost::format("%1% file not exist.") % file;
+        return -1;
+    }
     json j;
     std::list<std::string> different_settings_append;
     std::string new_support_style;
diff --git a/src/libslic3r/PresetBundle.cpp b/src/libslic3r/PresetBundle.cpp
index 0fb3b6e23..7cc50e3c8 100644
--- a/src/libslic3r/PresetBundle.cpp
+++ b/src/libslic3r/PresetBundle.cpp
@@ -3676,6 +3676,10 @@ std::pair<PresetsConfigSubstitutions, size_t> PresetBundle::load_vendor_configs_
     for (auto& machine_model : machine_model_subfiles)
     {
         std::string subfile = path + "/" + vendor_name + "/" + machine_model.second;
+        if (!boost::filesystem::exists(subfile)) {
+            BOOST_LOG_TRIVIAL(error) << __FUNCTION__ << boost::format("%1% file not exist.") % subfile;
+            continue;
+        }
         VendorProfile::PrinterModel model;
         model.id = machine_model.first;
         try {
diff --git a/src/slic3r/GUI/GUI_App.cpp b/src/slic3r/GUI/GUI_App.cpp
index 8192080ce..500533e61 100644
--- a/src/slic3r/GUI/GUI_App.cpp
+++ b/src/slic3r/GUI/GUI_App.cpp
@@ -2372,8 +2372,7 @@ void GUI_App::init_app_config()
             BOOST_LOG_TRIVIAL(error) << __FUNCTION__
             << "Configuration file may be corrupted and is not able to be parsed.Please delete the file and try again.";
             throw Slic3r::RuntimeError(
-                _u8L("BambuStudio configuration file may be corrupted and is not able to be parsed."
-                     "Please delete the file and try again.") +
+                _u8L("BambuStudio configuration file read failed. Please manually backup and delete it, and then restart BambuStudio software.") +
                 "\n\n" + app_config->config_path() + "\n\n" + error);
         }
         // Save orig_version here, so its empty if no app_config existed before this run.