diff --git a/cura/Settings/ContainerManager.py b/cura/Settings/ContainerManager.py
index 80a0d64474..08fdf707cf 100644
--- a/cura/Settings/ContainerManager.py
+++ b/cura/Settings/ContainerManager.py
@@ -345,6 +345,9 @@ class ContainerManager(QObject):
         # user changes are possibly added to make the current setup match the current enabled extruders
         machine_manager.correctExtruderSettings()
 
+        # The Print Sequence should be changed to match the current setup
+        machine_manager.correctPrintSequence()
+
         for container in send_emits_containers:
             container.sendPostponedEmits()
 
diff --git a/cura/Settings/MachineManager.py b/cura/Settings/MachineManager.py
index 58fd8171b5..1a2ab72a33 100755
--- a/cura/Settings/MachineManager.py
+++ b/cura/Settings/MachineManager.py
@@ -128,6 +128,7 @@ class MachineManager(QObject):
         self.activeQualityChangesGroupChanged.connect(self.activeQualityDisplayNameChanged)
 
         self.activeStackValueChanged.connect(self._reCalculateNumUserSettings)
+        self.numberExtrudersEnabledChanged.connect(self.correctPrintSequence)
 
     activeQualityDisplayNameChanged = pyqtSignal()
 
@@ -826,11 +827,6 @@ class MachineManager(QObject):
         result = []  # type: List[str]
         for setting_instance in container.findInstances():
             setting_key = setting_instance.definition.key
-            if setting_key == "print_sequence":
-                old_value = container.getProperty(setting_key, "value")
-                Logger.log("d", "Reset setting [%s] in [%s] because its old value [%s] is no longer valid", setting_key, container, old_value)
-                result.append(setting_key)
-                continue
             if not self._global_container_stack.getProperty(setting_key, "type") in ("extruder", "optional_extruder"):
                 continue
 
@@ -862,6 +858,41 @@ class MachineManager(QObject):
                 title = catalog.i18nc("@info:title", "Settings updated"))
             caution_message.show()
 
+    def correctPrintSequence(self) -> None:
+        """
+        Sets the Print Sequence setting to "all-at-once" when there are more than one enabled extruders.
+
+        This setting has to be explicitly changed whenever we have more than one enabled extruders to make sure that the
+        Cura UI is properly updated to reset all the UI elements changes that occur due to the one-at-a-time mode (such
+        as the reduced build volume, the different convex hulls of the objects etc.).
+        """
+
+        setting_key = "print_sequence"
+        new_value = "all_at_once"
+
+        if self._global_container_stack is None \
+                or self._global_container_stack.getProperty(setting_key, "value") == new_value \
+                or self.numberExtrudersEnabled < 2:
+            return
+
+        user_changes_container = self._global_container_stack.userChanges
+        quality_changes_container = self._global_container_stack.qualityChanges
+        print_sequence_quality_changes = quality_changes_container.getProperty(setting_key, "value")
+        print_sequence_user_changes = user_changes_container.getProperty(setting_key, "value")
+
+        # If the user changes container has a value and its the incorrect value, then reset the setting in the user
+        # changes (so that the circular revert-changes arrow will now show up in the interface)
+        if print_sequence_user_changes and print_sequence_user_changes != new_value:
+            user_changes_container.removeInstance(setting_key)
+            Logger.log("d", "Resetting '{}' in container '{}' because there are more than 1 enabled extruders.".format(setting_key, user_changes_container))
+        # If the print sequence doesn't exist in either the user changes or the quality changes (yet it still has the
+        # wrong value in the global stack), or it exists in the quality changes and it has the wrong value, then set it
+        # in the user changes
+        elif (not print_sequence_quality_changes and not print_sequence_user_changes) \
+                or (print_sequence_quality_changes and print_sequence_quality_changes != new_value):
+            user_changes_container.setProperty(setting_key, "value", new_value)
+            Logger.log("d", "Setting '{}' in '{}' to '{}' because there are more than 1 enabled extruders.".format(setting_key, user_changes_container, new_value))
+
     def setActiveMachineExtruderCount(self, extruder_count: int) -> None:
         """Set the amount of extruders on the active machine (global stack)
 
diff --git a/tests/TestMachineManager.py b/tests/TestMachineManager.py
index 4f15a0670c..788b8eee41 100644
--- a/tests/TestMachineManager.py
+++ b/tests/TestMachineManager.py
@@ -21,7 +21,8 @@ def machine_manager(application, extruder_manager, container_registry, global_st
     application.getGlobalContainerStack = MagicMock(return_value = global_stack)
     with patch("cura.Settings.CuraContainerRegistry.CuraContainerRegistry.getInstance", MagicMock(return_value=container_registry)):
         manager = MachineManager(application)
-        manager._onGlobalContainerChanged()
+        with patch.object(MachineManager, "updateNumberExtrudersEnabled", return_value = None):
+            manager._onGlobalContainerChanged()
 
     return manager
 
@@ -253,4 +254,4 @@ def test_isActiveQualityNotSupported(machine_manager):
 
 def test_isActiveQualityNotSupported_noQualityGroup(machine_manager):
     machine_manager.activeQualityGroup = MagicMock(return_value=None)
-    assert not machine_manager.isActiveQualitySupported
\ No newline at end of file
+    assert not machine_manager.isActiveQualitySupported