diff --git a/resources/qml/Menus/ConfigurationMenu/CustomConfiguration.qml b/resources/qml/Menus/ConfigurationMenu/CustomConfiguration.qml
index 6f3d6ffa17..fda9ee35ac 100644
--- a/resources/qml/Menus/ConfigurationMenu/CustomConfiguration.qml
+++ b/resources/qml/Menus/ConfigurationMenu/CustomConfiguration.qml
@@ -221,6 +221,7 @@ Item
 
                 OldControls.CheckBox
                 {
+                    id: enabledCheckbox
                     checked: Cura.MachineManager.activeStack != null ? Cura.MachineManager.activeStack.isEnabled : false
                     enabled: !checked || Cura.MachineManager.numberExtrudersEnabled > 1 //Disable if it's the last enabled extruder.
                     height: parent.height
@@ -265,6 +266,7 @@ Item
 
                     text: Cura.MachineManager.activeStack !== null ? Cura.MachineManager.activeStack.material.name : ""
                     tooltip: text
+                    enabled: enabledCheckbox.checked
 
                     width: selectors.controlWidth
                     height: parent.height
@@ -324,7 +326,8 @@ Item
                     height: parent.height
                     width: selectors.controlWidth
                     style: UM.Theme.styles.print_setup_header_button
-                    activeFocusOnPress: true;
+                    activeFocusOnPress: true
+                    enabled: enabledCheckbox.checked
 
                     menu: Cura.NozzleMenu { extruderIndex: Cura.ExtruderManager.activeExtruderIndex }
                 }
diff --git a/resources/qml/Menus/MaterialMenu.qml b/resources/qml/Menus/MaterialMenu.qml
index a574e240d3..9720c81879 100644
--- a/resources/qml/Menus/MaterialMenu.qml
+++ b/resources/qml/Menus/MaterialMenu.qml
@@ -50,6 +50,7 @@ Menu
         {
             text: model.brand + " " + model.name
             checkable: true
+            enabled: Cura.MachineManager.activeMachine.extruderList[extruderIndex].isEnabled
             checked: model.root_material_id === menu.currentRootMaterialId
             onTriggered: Cura.MachineManager.setMaterial(extruderIndex, model.container_node)
             exclusiveGroup: favoriteGroup  // One favorite and one item from the others can be active at the same time.
@@ -72,6 +73,7 @@ Menu
             {
                 text: model.name
                 checkable: true
+                enabled: Cura.MachineManager.activeMachine.extruderList[extruderIndex].isEnabled
                 checked: model.root_material_id === menu.currentRootMaterialId
                 exclusiveGroup: group
                 onTriggered: Cura.MachineManager.setMaterial(extruderIndex, model.container_node)
@@ -110,6 +112,7 @@ Menu
                         {
                             text: model.name
                             checkable: true
+                            enabled: Cura.MachineManager.activeMachine.extruderList[extruderIndex].isEnabled
                             checked: model.id === menu.activeMaterialId
                             exclusiveGroup: group
                             onTriggered: Cura.MachineManager.setMaterial(extruderIndex, model.container_node)
diff --git a/resources/qml/Menus/NozzleMenu.qml b/resources/qml/Menus/NozzleMenu.qml
index a94ad10330..a291f125eb 100644
--- a/resources/qml/Menus/NozzleMenu.qml
+++ b/resources/qml/Menus/NozzleMenu.qml
@@ -32,7 +32,7 @@ Menu
                 return extruder.variant.name == model.hotend_name
             }
             exclusiveGroup: group
-
+            enabled: Cura.MachineManager.activeMachine.extruderList[extruderIndex].isEnabled
             onTriggered: {
                 Cura.MachineManager.setVariant(menu.extruderIndex, model.container_node);
             }