diff --git a/cura/Settings/MachineManager.py b/cura/Settings/MachineManager.py
index d33bf636d3..ab3701c1eb 100644
--- a/cura/Settings/MachineManager.py
+++ b/cura/Settings/MachineManager.py
@@ -225,11 +225,26 @@ class MachineManager(QObject):
             self._global_container_stack.nameChanged.connect(self._onMachineNameChanged)
             self._global_container_stack.containersChanged.connect(self._onInstanceContainersChanged)
             self._global_container_stack.propertyChanged.connect(self._onPropertyChanged)
-            material = self._global_container_stack.findContainer({"type": "material"})
-            material.nameChanged.connect(self._onMaterialNameChanged)
 
-            quality = self._global_container_stack.findContainer({"type": "quality"})
-            quality.nameChanged.connect(self._onQualityNameChanged)
+            if self._global_container_stack.getProperty("machine_extruder_count", "value") > 1:
+                # For multi-extrusion machines, we do not want variant or material profiles in the stack,
+                # because these are extruder specific and may cause wrong values to be used for extruders
+                # that did not specify a value in the extruder.
+                global_variant = self._global_container_stack.findContainer(type = "variant")
+                if global_variant != self._empty_variant_container:
+                    self._global_container_stack.replaceContainer(self._global_container_stack.getContainerIndex(global_variant), self._empty_variant_container)
+
+                global_material = self._global_container_stack.findContainer(type = "material")
+                if global_material != self._empty_material_container:
+                    self._global_container_stack.replaceContainer(self._global_container_stack.getContainerIndex(global_material), self._empty_material_container)
+
+            else:
+                material = self._global_container_stack.findContainer({"type": "material"})
+                material.nameChanged.connect(self._onMaterialNameChanged)
+
+                quality = self._global_container_stack.findContainer({"type": "quality"})
+                quality.nameChanged.connect(self._onQualityNameChanged)
+
 
     def _onActiveExtruderStackChanged(self):
         self.blurSettings.emit()  # Ensure no-one has focus.