diff --git a/cura/Machines/Models/QualityProfilesModel.py b/cura/Machines/Models/QualityProfilesModel.py
index 034852a101..2f1374cc8b 100644
--- a/cura/Machines/Models/QualityProfilesModel.py
+++ b/cura/Machines/Models/QualityProfilesModel.py
@@ -48,12 +48,18 @@ class QualityProfilesModel(ListModel):
     def _update(self):
         Logger.log("d", "Updating quality profile model ...")
 
-        active_global_stack = Application.getInstance().getMachineManager()._global_container_stack
+        machine_manager = Application.getInstance().getMachineManager()
+        active_global_stack = machine_manager._global_container_stack
         if active_global_stack is None:
             self.setItems([])
             Logger.log("d", "No active GlobalStack, set quality profile model as empty.")
             return
 
+        # Check for material compatibility
+        if not machine_manager.activeMaterialsCompatible():
+            self.setItems([])
+            return
+
         quality_group_dict = self._quality_manager.getQualityGroups(active_global_stack)
 
         item_list = []
diff --git a/cura/Settings/MachineManager.py b/cura/Settings/MachineManager.py
index 3844879081..5673039497 100755
--- a/cura/Settings/MachineManager.py
+++ b/cura/Settings/MachineManager.py
@@ -1018,6 +1018,13 @@ class MachineManager(QObject):
             self._current_root_material_id[position] = root_material_id
             self.rootMaterialChanged.emit()
 
+    def activeMaterialsCompatible(self):
+        # check material - variant compatibility
+        for position, extruder in self._global_container_stack.extruders.items():
+            if not extruder.material.getMetaDataEntry("compatible"):
+                return False
+        return True
+
     ## Update current quality type and machine after setting material
     def _updateQualityWithMaterial(self):
         current_quality = None
@@ -1027,6 +1034,11 @@ class MachineManager(QObject):
         candidate_quality_groups = quality_manager.getQualityGroups(self._global_container_stack)
         available_quality_types = {qt for qt, g in candidate_quality_groups.items() if g.is_available}
 
+        if not self.activeMaterialsCompatible:
+            Logger.log("d", "Material [%s] is not compatible, setting empty material." % str(extruder.material))
+            self._setEmptyQuality()
+            return
+
         if not available_quality_types:
             self._setEmptyQuality()
             return