diff --git a/cura/Settings/MachineManager.py b/cura/Settings/MachineManager.py
index 2051ce1b99..27d8fbbc78 100755
--- a/cura/Settings/MachineManager.py
+++ b/cura/Settings/MachineManager.py
@@ -904,6 +904,7 @@ class MachineManager(QObject):
 
         if self._global_container_stack is None \
                 or self._global_container_stack.getProperty(setting_key, "value") == new_value \
+                or self._global_container_stack.definitionChanges.getProperty("extruders_enabled_count", "value") is None \
                 or self._global_container_stack.definitionChanges.getProperty("extruders_enabled_count", "value") < 2:
             return