diff --git a/cura/Settings/MachineManager.py b/cura/Settings/MachineManager.py
index 31ea691e76..f78a21aaad 100755
--- a/cura/Settings/MachineManager.py
+++ b/cura/Settings/MachineManager.py
@@ -747,6 +747,11 @@ class MachineManager(QObject):
         result = []  # type: List[str]
         for setting_instance in container.findInstances():
             setting_key = setting_instance.definition.key
+            if setting_key == "print_sequence":
+                old_value = container.getProperty(setting_key, "value")
+                Logger.log("d", "Reset setting [%s] in [%s] because its old value [%s] is no longer valid", setting_key, container, old_value)
+                result.append(setting_key)
+                continue
             if not self._global_container_stack.getProperty(setting_key, "type") in ("extruder", "optional_extruder"):
                 continue
 
diff --git a/resources/definitions/fdmprinter.def.json b/resources/definitions/fdmprinter.def.json
index b5d423c28b..22eecd8f58 100644
--- a/resources/definitions/fdmprinter.def.json
+++ b/resources/definitions/fdmprinter.def.json
@@ -5984,7 +5984,7 @@
                 "print_sequence":
                 {
                     "label": "Print Sequence",
-                    "description": "Whether to print all models one layer at a time or to wait for one model to finish, before moving on to the next. One at a time mode is only possible if all models are separated in such a way that the whole print head can move in between and all models are lower than the distance between the nozzle and the X/Y axes.",
+                    "description": "Whether to print all models one layer at a time or to wait for one model to finish, before moving on to the next. One at a time mode is possible if a) only one extruder is enabled and b) all models are separated in such a way that the whole print head can move in between and all models are lower than the distance between the nozzle and the X/Y axes. ",
                     "type": "enum",
                     "options":
                     {