diff --git a/cura/Settings/ProfilesModel.py b/cura/Settings/ProfilesModel.py
index 331292e255..fb3e107ee6 100644
--- a/cura/Settings/ProfilesModel.py
+++ b/cura/Settings/ProfilesModel.py
@@ -100,8 +100,12 @@ class ProfilesModel(InstanceContainersModel):
         extruder_stacks = extruder_manager.getActiveExtruderStacks()
         if multiple_extrusion:
             # Place the active extruder at the front of the list.
-            extruder_stacks.remove(active_extruder)
-            extruder_stacks = [active_extruder] + extruder_stacks
+            if active_extruder in extruder_stacks:
+                extruder_stacks.remove(active_extruder)
+            new_extruder_stacks = []
+            if active_extruder is not None:
+                new_extruder_stacks = [active_extruder]
+            extruder_stacks = new_extruder_stacks + extruder_stacks
 
         # Get a list of usable/available qualities for this machine and material
         qualities = QualityManager.getInstance().findAllUsableQualitiesForMachineAndExtruders(global_container_stack,
diff --git a/cura/Settings/UserProfilesModel.py b/cura/Settings/UserProfilesModel.py
index b9710f7df2..223900306b 100644
--- a/cura/Settings/UserProfilesModel.py
+++ b/cura/Settings/UserProfilesModel.py
@@ -33,8 +33,12 @@ class UserProfilesModel(ProfilesModel):
         extruder_stacks = extruder_manager.getActiveExtruderStacks()
         if multiple_extrusion:
             # Place the active extruder at the front of the list.
-            extruder_stacks.remove(active_extruder)
-            extruder_stacks = [active_extruder] + extruder_stacks
+            if active_extruder in extruder_stacks:
+                extruder_stacks.remove(active_extruder)
+            new_extruder_stacks = []
+            if active_extruder is not None:
+                new_extruder_stacks = [active_extruder]
+            extruder_stacks = new_extruder_stacks + extruder_stacks
 
         # Fetch the list of useable qualities across all extruders.
         # The actual list of quality profiles come from the first extruder in the extruder list.