diff --git a/src/libslic3r/PrintApply.cpp b/src/libslic3r/PrintApply.cpp
index fe3e689630..698edbf3b6 100644
--- a/src/libslic3r/PrintApply.cpp
+++ b/src/libslic3r/PrintApply.cpp
@@ -1080,7 +1080,8 @@ Print::ApplyStatus Print::apply(const Model &model, DynamicPrintConfig new_full_
         if (solid_or_modifier_differ || model_origin_translation_differ || layer_height_ranges_differ ||
             ! model_object.layer_height_profile.timestamp_matches(model_object_new.layer_height_profile)) {
             // The very first step (the slicing step) is invalidated. One may freely remove all associated PrintObjects.
-            model_object_status.print_object_regions_status = model_origin_translation_differ || layer_height_ranges_differ ?
+            model_object_status.print_object_regions_status = 
+                model_object_status.print_object_regions == nullptr || model_origin_translation_differ || layer_height_ranges_differ ?
                 // Drop print_objects_regions.
                 ModelObjectStatus::PrintObjectRegionsStatus::Invalid :
                 // Reuse bounding boxes of print_objects_regions for ModelVolumes with unmodified transformation.
@@ -1092,7 +1093,7 @@ Print::ApplyStatus Print::apply(const Model &model, DynamicPrintConfig new_full_
             if (model_object_status.print_object_regions_status == ModelObjectStatus::PrintObjectRegionsStatus::PartiallyValid)
                 // Drop everything from PrintObjectRegions but those VolumeExtents (of their particular ModelVolumes) that are still valid.
                 print_objects_regions_invalidate_keep_some_volumes(*model_object_status.print_object_regions, model_object.volumes, model_object_new.volumes);
-            else
+            else if (model_object_status.print_object_regions != nullptr)
                 model_object_status.print_object_regions->clear();
             // Copy content of the ModelObject including its ID, do not change the parent.
             model_object.assign_copy(model_object_new);