diff --git a/CMakeLists.txt b/CMakeLists.txt
index a37e7a1b92..554e507d90 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -33,6 +33,9 @@ option(SLIC3R_MSVC_COMPILE_PARALLEL "Compile on Visual Studio in parallel" 1)
 option(SLIC3R_MSVC_PDB          "Generate PDB files on MSVC in Release mode" 1)
 option(SLIC3R_PERL_XS           "Compile XS Perl module and enable Perl unit and integration tests" 0)
 option(SLIC3R_ASAN              "Enable ASan on Clang and GCC" 0)
+option(SLIC3R_MSAN              "Enable MemorySanitizer on Clang for Linux" 0)
+option(SLIC3R_MSAN_RECOVERY     "Enable recovery from an error after an initialized value is found" 1) # It is enabled by default until all reports are investigated.
+option(SLIC3R_MSAN_ORIGIN_TRACKING "Enable tracking origins of uninitialized values" 0) # It causes another slows down of program execution by a factor of 1.5x-2x.
 # If SLIC3R_FHS is 1 -> SLIC3R_DESKTOP_INTEGRATION is always 0, othrewise variable.
 CMAKE_DEPENDENT_OPTION(SLIC3R_DESKTOP_INTEGRATION "Allow perfoming desktop integration during runtime" 1 "NOT SLIC3R_FHS" 0)
 
@@ -249,6 +252,44 @@ if (NOT MSVC AND ("${CMAKE_CXX_COMPILER_ID}" STREQUAL "GNU" OR "${CMAKE_CXX_COMP
 
 endif()
 
+if (SLIC3R_MSAN)
+    if (NOT CMAKE_CXX_COMPILER_ID STREQUAL Clang)
+        message(FATAL_ERROR "MemorySanitizer is available only in Clang.")
+    endif ()
+
+    if (SLIC3R_ASAN)
+        message(FATAL_ERROR "MemorySanitizer cannot be used at the same time as AddressSanitizer.")
+    endif ()
+
+    if (NOT CMAKE_CXX_COMPILER_VERSION VERSION_EQUAL 12)
+        message(WARNING "MemorySanitizer builds are tested only with CLANG 12, other versions are untested but could be working.")
+    endif()
+
+    add_compile_options(-nostdinc++)
+    add_compile_options(-stdlib=libc++)
+    add_compile_options(-fsanitize=memory)
+    add_compile_options(-fno-omit-frame-pointer)
+
+    include_directories(${CMAKE_PREFIX_PATH}/include)
+    include_directories(${CMAKE_PREFIX_PATH}/include/c++/v1)
+    link_directories(${CMAKE_PREFIX_PATH}/lib)
+
+    # Some libraries aren't correctly found without -Wl,--disable-new-dtags. https://stackoverflow.com/a/47243544
+    set(_msan_linker_flags "-fsanitize=memory -stdlib=libc++ -L${CMAKE_PREFIX_PATH}/lib -Wl,--disable-new-dtags -Wl,--rpath='$ORIGIN/../lib'")
+    if (SLIC3R_MSAN_RECOVERY)
+        add_compile_options(-fsanitize-recover=memory)
+        set(_msan_linker_flags "${_msan_linker_flags} -fsanitize-recover=memory")
+    endif ()
+    if (SLIC3R_MSAN_ORIGIN_TRACKING)
+        add_compile_options(-fsanitize-memory-track-origins=2)
+        set(_msan_linker_flags "${_msan_linker_flags} -fsanitize-memory-track-origins=2")
+    endif ()
+
+    set(CMAKE_EXE_LINKER_FLAGS "${CMAKE_EXE_LINKER_FLAGS} ${_msan_linker_flags}")
+    set(CMAKE_SHARED_LINKER_FLAGS "${CMAKE_SHARED_LINKER_FLAGS} ${_msan_linker_flags}")
+    set(CMAKE_MODULE_LINKER_FLAGS "${CMAKE_MODULE_LINKER_FLAGS} ${_msan_linker_flags}")
+endif ()
+
 if (SLIC3R_ASAN)
     # ASAN should be available on MSVC starting with Visual Studio 2019 16.9
     # https://devblogs.microsoft.com/cppblog/address-sanitizer-for-msvc-now-generally-available/
@@ -634,6 +675,14 @@ else ()
     install(FILES src/platform/unix/PrusaSlicer.desktop DESTINATION ${CMAKE_INSTALL_PREFIX}/resources/applications)
     install(FILES src/platform/unix/PrusaGcodeviewer.desktop DESTINATION ${CMAKE_INSTALL_PREFIX}/resources/applications)
     install(DIRECTORY "${SLIC3R_RESOURCES_DIR}/" DESTINATION "${CMAKE_INSTALL_PREFIX}/resources")
+
+    if (SLIC3R_MSAN)
+        install(CODE "set(_MSAN_COPY_FROM \"${CMAKE_PREFIX_PATH}/../lib\")")
+        install(CODE "set(_MSAN_COPY_TO \"${CMAKE_INSTALL_PREFIX}/lib\")")
+        install(SCRIPT deps/MSan_Deps/Chromium_prebuilt_libraries/copy_chromium_prebuilt_libraries.cmake)
+        install(CODE "set(_MSAN_COPY_FROM \"${CMAKE_PREFIX_PATH}/lib\")")
+        install(SCRIPT deps/MSan_Deps/install_msan_shared_libraries.cmake)
+    endif ()
 endif ()
 
 configure_file(${LIBDIR}/platform/unix/fhs.hpp.in ${LIBDIR_BIN}/platform/unix/fhs.hpp)
diff --git a/deps/Blosc/Blosc.cmake b/deps/Blosc/Blosc.cmake
index 45c45c7c9e..8d0937bb5e 100644
--- a/deps/Blosc/Blosc.cmake
+++ b/deps/Blosc/Blosc.cmake
@@ -11,7 +11,7 @@ prusaslicer_add_cmake_project(Blosc
     #URL_HASH SHA256=7463a1df566704f212263312717ab2c36b45d45cba6cd0dccebf91b2cc4b4da9
     URL https://github.com/tamasmeszaros/c-blosc/archive/refs/heads/v1.17.0_tm.zip
     URL_HASH SHA256=dcb48bf43a672fa3de6a4b1de2c4c238709dad5893d1e097b8374ad84b1fc3b3
-    DEPENDS ${ZLIB_PKG}
+    DEPENDS ${LIBCXX_PKG} ${ZLIB_PKG}
     # Patching upstream does not work this way with git version 2.28 installed on mac worker
     # PATCH_COMMAND  ${GIT_EXECUTABLE} apply --ignore-space-change --whitespace=fix ${CMAKE_CURRENT_LIST_DIR}/blosc-mods.patch
     CMAKE_ARGS
@@ -21,6 +21,7 @@ prusaslicer_add_cmake_project(Blosc
         -DBUILD_TESTS=OFF 
         -DBUILD_BENCHMARKS=OFF 
         -DPREFER_EXTERNAL_ZLIB=ON
+        ${MSAN_CMAKE_ARGS}
 )
 
 if (MSVC)
diff --git a/deps/Boost/Boost.cmake b/deps/Boost/Boost.cmake
index ae2bd96466..96d8ecabc3 100644
--- a/deps/Boost/Boost.cmake
+++ b/deps/Boost/Boost.cmake
@@ -35,7 +35,13 @@ elseif (CMAKE_CXX_COMPILER_ID STREQUAL "Clang")
     if (WIN32)
         set(_boost_toolset "clang-win")
     else()
-        set(_boost_toolset "clang")
+        if (DEP_MSAN)
+            configure_file(${CMAKE_CURRENT_LIST_DIR}/msan-user-config.jam boost-user-config.jam)
+            set(_boost_toolset clang)
+            set(_patch_command ${_patch_command} && ${CMAKE_COMMAND} -E copy ${CMAKE_CURRENT_BINARY_DIR}/boost-user-config.jam ./tools/build/src/tools/user-config.jam)
+        else ()
+            set(_boost_toolset "clang")
+        endif()
     endif()
 elseif (CMAKE_CXX_COMPILER_ID STREQUAL "Intel")
     set(_boost_toolset "intel")
@@ -68,8 +74,15 @@ ProcessorCount(NPROC)
 file(TO_NATIVE_PATH ${DESTDIR}/usr/local/ _prefix)
 
 set(_boost_flags "")
-if (UNIX) 
-    set(_boost_flags "cflags=-fPIC;cxxflags=-fPIC")
+if (UNIX)
+    if (DEP_MSAN)
+        set(_boost_flags
+                "cflags=-fPIC ${MSAN_CMAKE_C_FLAGS};"
+                "cxxflags=-fPIC ${MSAN_CMAKE_CXX_FLAGS};"
+                "linkflags=-fPIC ${MSAN_CMAKE_LD_FLAGS}")
+    else()
+        set(_boost_flags "cflags=-fPIC;cxxflags=-fPIC")
+    endif()
 elseif(APPLE)
     set(_boost_flags 
         "cflags=-fPIC -mmacosx-version-min=${DEP_OSX_TARGET};"
@@ -121,6 +134,7 @@ ExternalProject_Add(
     dep_Boost
     URL "https://boostorg.jfrog.io/artifactory/main/release/1.75.0/source/boost_1_75_0.tar.gz"
     URL_HASH SHA256=aeb26f80e80945e82ee93e5939baebdca47b9dee80a07d3144be1e1a6a66dd6a
+    DEPENDS ${LIBCXX_PKG}
     DOWNLOAD_DIR ${DEP_DOWNLOAD_DIR}/Boost
     CONFIGURE_COMMAND "${_bootstrap_cmd}"
     PATCH_COMMAND ${_patch_command}
diff --git a/deps/Boost/msan-user-config.jam b/deps/Boost/msan-user-config.jam
new file mode 100644
index 0000000000..f7107135ac
--- /dev/null
+++ b/deps/Boost/msan-user-config.jam
@@ -0,0 +1 @@
+using clang : : @CMAKE_CXX_COMPILER@ ;
\ No newline at end of file
diff --git a/deps/CGAL/CGAL.cmake b/deps/CGAL/CGAL.cmake
index b43467b539..f5905e40cb 100644
--- a/deps/CGAL/CGAL.cmake
+++ b/deps/CGAL/CGAL.cmake
@@ -5,7 +5,9 @@ prusaslicer_add_cmake_project(
     # For whatever reason, this keeps downloading forever (repeats downloads if finished)
     URL      https://github.com/CGAL/cgal/archive/releases/CGAL-5.0.zip
     URL_HASH SHA256=c2b035bd078687b6d8c0fb6371a7443adcdb647856af9969532c4050cd5f48e5
-    DEPENDS dep_Boost dep_GMP dep_MPFR
+    DEPENDS ${LIBCXX_PKG} dep_Boost dep_GMP dep_MPFR
+    CMAKE_ARGS
+        ${MSAN_CMAKE_ARGS}
 )
 
 include(GNUInstallDirs)
diff --git a/deps/CMakeLists.txt b/deps/CMakeLists.txt
index bc98e0b836..57f3ce783f 100644
--- a/deps/CMakeLists.txt
+++ b/deps/CMakeLists.txt
@@ -40,6 +40,12 @@ if(CMAKE_SYSTEM_NAME STREQUAL "Linux")
     option(DEP_WX_GTK3 "Build wxWidgets against GTK3" OFF)
 endif()
 
+if(CMAKE_SYSTEM_NAME STREQUAL "Linux")
+    option(DEP_MSAN                 "Enable MemorySanitizer on Clang for Linux" OFF)
+    option(DEP_MSAN_RECOVERY        "Enable recovery from an error after an initialized value is found" ON) # It is enabled by default until all reports are investigated.
+    option(DEP_MSAN_ORIGIN_TRACKING "Enable tracking origins of uninitialized values" OFF) # It causes another slows down of program execution by a factor of 1.5x-2x.
+endif()
+
 # On developer machines, it can be enabled to speed up compilation and suppress warnings coming from IGL. 
 # FIXME:
 # Enabling this option is not safe. IGL will compile itself with its own version of Eigen while
@@ -141,18 +147,64 @@ else()
     include("deps-linux.cmake")
 endif()
 
+if (DEP_MSAN)
+    if (NOT CMAKE_CXX_COMPILER_ID STREQUAL Clang)
+        message(FATAL_ERROR "MemorySanitizer is available only in Clang.")
+    endif ()
+
+    if (NOT CMAKE_CXX_COMPILER_VERSION VERSION_EQUAL 12)
+        message(WARNING "MemorySanitizer builds are tested only with CLANG 12, other versions are untested but could be working.")
+    endif()
+
+    file(MAKE_DIRECTORY ${DESTDIR}/usr/lib)
+
+    include(MSan_Deps/Libcxx/Libcxx.cmake)
+    include(MSan_Deps/Chromium_prebuilt_libraries/Chromium.cmake)
+    include(MSan_Deps/LLVM/LLVM.cmake)
+    include(MSan_Deps/Mesa3D/Mesa3D.cmake)
+    include(MSan_Deps/fontconfig/fontconfig.cmake)
+
+    set(_msan_linker_flags "-fsanitize=memory")
+    if (DEP_MSAN_RECOVERY)
+        set(_msan_linker_flags "${_msan_linker_flags} -fsanitize-recover=memory")
+    endif ()
+    if (DEP_MSAN_ORIGIN_TRACKING)
+        set(_msan_linker_flags "${_msan_linker_flags} -fsanitize-memory-track-origins=2")
+    endif ()
+    set(_msan_common_flags   "${_msan_linker_flags} -fno-omit-frame-pointer")
+    set(_msan_only_cxx_flags "-nostdinc++ -stdlib=libc++ -isystem ${DESTDIR}/usr/local/include -isystem ${DESTDIR}/usr/local/include/c++/v1")
+    set(_msan_only_ld_flags  "-nostdinc++ -stdlib=libc++ -L${DESTDIR}/usr/local/lib -Wl,--rpath=${DESTDIR}/usr/local/lib")
+
+    # For dependencies that are configure using CFLAGS, CXXFLAGS and LDFLAGS instead of CMAKE_*_FLAGS.
+    set(MSAN_CMAKE_C_FLAGS   "${_msan_common_flags}")
+    set(MSAN_CMAKE_CXX_FLAGS "${_msan_common_flags} ${_msan_only_cxx_flags}")
+    set(MSAN_CMAKE_LD_FLAGS  "${_msan_common_flags} ${_msan_only_ld_flags}")
+
+    set(_msan_all_flags  "${_msan_common_flags} ${_msan_only_cxx_flags} ${_msan_only_ld_flags}")
+    set(MSAN_CMAKE_ARGS ${_MSAN_CMAKE_ARGS}
+            -DCMAKE_C_FLAGS:STRING=${MSAN_CMAKE_C_FLAGS}
+            -DCMAKE_CXX_FLAGS:STRING=${_msan_all_flags})
+
+    set(LIBCXX_PKG dep_Libcxx)
+    set(FONTCONFIG_PKG dep_fontconfig)
+else ()
+    set(MSAN_CMAKE_ARGS "")
+    set(LIBCXX_PKG "")
+    set(FONTCONFIG_PKG "")
+endif ()
+
 set(ZLIB_PKG "")
-if (NOT ZLIB_FOUND) 
+if (NOT ZLIB_FOUND OR DEP_MSAN)
     include(ZLIB/ZLIB.cmake)
     set(ZLIB_PKG dep_ZLIB)
 endif ()
 set(PNG_PKG "")
-if (NOT PNG_FOUND) 
+if (NOT PNG_FOUND OR DEP_MSAN)
     include(PNG/PNG.cmake)
     set(PNG_PKG dep_PNG)
 endif ()
 set(EXPAT_PKG "")
-if (NOT EXPAT_FOUND) 
+if (NOT EXPAT_FOUND OR DEP_MSAN)
     include(EXPAT/EXPAT.cmake)
     set(EXPAT_PKG dep_EXPAT)
 endif ()
@@ -209,6 +261,10 @@ else()
     #list(APPEND _dep_list "dep_libigl")
 endif()
 
+if (DEP_MSAN)
+    list(APPEND _dep_list "dep_LLVM;dep_Mesa3D;dep_fontconfig;dep_Chromium_Libs")
+endif ()
+
 add_custom_target(deps ALL DEPENDS ${_dep_list})
 
 # Note: I'm not using any of the LOG_xxx options in ExternalProject_Add() commands
diff --git a/deps/CURL/CURL.cmake b/deps/CURL/CURL.cmake
index a05a4e97e9..e0d93fd9a8 100644
--- a/deps/CURL/CURL.cmake
+++ b/deps/CURL/CURL.cmake
@@ -59,7 +59,7 @@ prusaslicer_add_cmake_project(CURL
   # GIT_TAG             curl-7_75_0
   URL                 https://github.com/curl/curl/archive/refs/tags/curl-7_75_0.zip
   URL_HASH            SHA256=a63ae025bb0a14f119e73250f2c923f4bf89aa93b8d4fafa4a9f5353a96a765a
-  DEPENDS             ${ZLIB_PKG}
+  DEPENDS             ${LIBCXX_PKG} ${ZLIB_PKG}
   # PATCH_COMMAND       ${GIT_EXECUTABLE} checkout -f -- . && git clean -df && 
   #                     ${GIT_EXECUTABLE} apply --whitespace=fix ${CMAKE_CURRENT_LIST_DIR}/curl-mods.patch
   CMAKE_ARGS
@@ -67,6 +67,7 @@ prusaslicer_add_cmake_project(CURL
     -DCMAKE_POSITION_INDEPENDENT_CODE=ON
     -DCURL_STATICLIB=${_curl_static}
     ${_curl_platform_flags}
+    ${MSAN_CMAKE_ARGS}
 )
 
 if (CMAKE_SYSTEM_NAME STREQUAL "Linux")
diff --git a/deps/Cereal/Cereal.cmake b/deps/Cereal/Cereal.cmake
index 28912ff4ff..2378c9e588 100644
--- a/deps/Cereal/Cereal.cmake
+++ b/deps/Cereal/Cereal.cmake
@@ -1,6 +1,8 @@
 prusaslicer_add_cmake_project(Cereal
     URL "https://github.com/USCiLab/cereal/archive/v1.2.2.tar.gz"
     URL_HASH SHA256=1921f26d2e1daf9132da3c432e2fd02093ecaedf846e65d7679ddf868c7289c4
+    DEPENDS ${LIBCXX_PKG}
     CMAKE_ARGS
         -DJUST_INSTALL_CEREAL=on
+        ${MSAN_CMAKE_ARGS}
 )
\ No newline at end of file
diff --git a/deps/EXPAT/EXPAT.cmake b/deps/EXPAT/EXPAT.cmake
index ed5eb220f4..1aac605dd2 100644
--- a/deps/EXPAT/EXPAT.cmake
+++ b/deps/EXPAT/EXPAT.cmake
@@ -2,6 +2,9 @@ prusaslicer_add_cmake_project(EXPAT
   # GIT_REPOSITORY https://github.com/nigels-com/glew.git
   # GIT_TAG 3a8eff7 # 2.1.0
   SOURCE_DIR          ${CMAKE_CURRENT_LIST_DIR}/expat
+  DEPENDS ${LIBCXX_PKG}
+  CMAKE_ARGS
+        ${MSAN_CMAKE_ARGS}
 )
 
 if (MSVC)
diff --git a/deps/GLEW/GLEW.cmake b/deps/GLEW/GLEW.cmake
index 5916ce7eb7..98b6f5dddb 100644
--- a/deps/GLEW/GLEW.cmake
+++ b/deps/GLEW/GLEW.cmake
@@ -5,6 +5,9 @@ find_package(OpenGL QUIET REQUIRED)
 prusaslicer_add_cmake_project(
   GLEW
   SOURCE_DIR  ${CMAKE_CURRENT_LIST_DIR}/glew
+  DEPENDS ${LIBCXX_PKG}
+  CMAKE_ARGS
+        ${MSAN_CMAKE_ARGS}
 )
 
 if (MSVC)
diff --git a/deps/GMP/GMP.cmake b/deps/GMP/GMP.cmake
index 6b0f970852..4a80159a1b 100644
--- a/deps/GMP/GMP.cmake
+++ b/deps/GMP/GMP.cmake
@@ -17,9 +17,15 @@ if (MSVC)
     add_custom_target(dep_GMP SOURCES ${_output})
 
 else ()
-    set(_gmp_ccflags "-O2 -DNDEBUG -fPIC -DPIC -Wall -Wmissing-prototypes -Wpointer-arith -pedantic -fomit-frame-pointer -fno-common")
+    set(_gmp_ccflags   "-O2 -DNDEBUG -fPIC -DPIC -Wall -Wmissing-prototypes -Wpointer-arith -pedantic -fomit-frame-pointer -fno-common")
+    set(_gmp_cxxflags  "${_gmp_ccflags}")
     set(_gmp_build_tgt "${CMAKE_SYSTEM_PROCESSOR}")
 
+    if (DEP_MSAN)
+        set(_gmp_ccflags  "${_gmp_ccflags} ${MSAN_CMAKE_C_FLAGS}")
+        set(_gmp_cxxflags "${_gmp_cxxflags} ${MSAN_CMAKE_CXX_FLAGS} ${MSAN_CMAKE_LD_FLAGS} ${MSAN_CMAKE_RPATH}")
+    endif ()
+
     if (APPLE)
         if (${CMAKE_SYSTEM_PROCESSOR} MATCHES "arm")
             set(_gmp_build_tgt aarch64)
@@ -45,9 +51,10 @@ else ()
     ExternalProject_Add(dep_GMP
         URL https://gmplib.org/download/gmp/gmp-6.2.1.tar.bz2
         URL_HASH SHA256=eae9326beb4158c386e39a356818031bd28f3124cf915f8c5b1dc4c7a36b4d7c
+        DEPENDS ${LIBCXX_PKG}
         DOWNLOAD_DIR ${DEP_DOWNLOAD_DIR}/GMP
-        BUILD_IN_SOURCE ON 
-        CONFIGURE_COMMAND  env "CFLAGS=${_gmp_ccflags}" "CXXFLAGS=${_gmp_ccflags}" ./configure ${_cross_compile_arg} --enable-shared=no --enable-cxx=yes --enable-static=yes "--prefix=${DESTDIR}/usr/local" ${_gmp_build_tgt}
+        BUILD_IN_SOURCE ON
+        CONFIGURE_COMMAND env "CFLAGS=${_gmp_ccflags}" "CXXFLAGS=${_gmp_cxxflags}" ./configure ${_cross_compile_arg} --enable-shared=no --enable-cxx=yes --enable-static=yes "--prefix=${DESTDIR}/usr/local" ${_gmp_build_tgt}
         BUILD_COMMAND     make -j
         INSTALL_COMMAND   make install
     )
diff --git a/deps/JPEG/JPEG.cmake b/deps/JPEG/JPEG.cmake
index 4c8c0307e5..36d66d55cc 100644
--- a/deps/JPEG/JPEG.cmake
+++ b/deps/JPEG/JPEG.cmake
@@ -1,8 +1,9 @@
 prusaslicer_add_cmake_project(JPEG
     URL https://github.com/libjpeg-turbo/libjpeg-turbo/archive/refs/tags/2.0.6.zip
     URL_HASH SHA256=017bdc33ff3a72e11301c0feb4657cb27719d7f97fa67a78ed506c594218bbf1
-    DEPENDS ${ZLIB_PKG}
+    DEPENDS ${LIBCXX_PKG} ${ZLIB_PKG}
     CMAKE_ARGS
         -DENABLE_SHARED=OFF
         -DENABLE_STATIC=ON
+        ${MSAN_CMAKE_ARGS}
 )
diff --git a/deps/MPFR/MPFR.cmake b/deps/MPFR/MPFR.cmake
index c29bb39ad0..c4ab18d799 100644
--- a/deps/MPFR/MPFR.cmake
+++ b/deps/MPFR/MPFR.cmake
@@ -28,9 +28,10 @@ else ()
     ExternalProject_Add(dep_MPFR
         URL http://ftp.vim.org/ftp/gnu/mpfr/mpfr-3.1.6.tar.bz2 https://www.mpfr.org/mpfr-3.1.6/mpfr-3.1.6.tar.bz2  # mirrors are allowed
         URL_HASH SHA256=cf4f4b2d80abb79e820e78c8077b6725bbbb4e8f41896783c899087be0e94068
+        DEPENDS ${LIBCXX_PKG}
         DOWNLOAD_DIR ${DEP_DOWNLOAD_DIR}/MPFR
         BUILD_IN_SOURCE ON
-        CONFIGURE_COMMAND env "CFLAGS=${_gmp_ccflags}" "CXXFLAGS=${_gmp_ccflags}" ./configure ${_cross_compile_arg} --prefix=${DESTDIR}/usr/local --enable-shared=no --enable-static=yes --with-gmp=${DESTDIR}/usr/local ${_gmp_build_tgt}
+        CONFIGURE_COMMAND env "CFLAGS=${_gmp_ccflags}" "CXXFLAGS=${_gmp_cxxflags}" ./configure ${_cross_compile_arg} --prefix=${DESTDIR}/usr/local --enable-shared=no --enable-static=yes --with-gmp=${DESTDIR}/usr/local ${_gmp_build_tgt}
         BUILD_COMMAND make -j
         INSTALL_COMMAND make install
         DEPENDS dep_GMP
diff --git a/deps/MSan_Deps/Chromium_prebuilt_libraries/Chromium.cmake b/deps/MSan_Deps/Chromium_prebuilt_libraries/Chromium.cmake
new file mode 100644
index 0000000000..53ce81f766
--- /dev/null
+++ b/deps/MSan_Deps/Chromium_prebuilt_libraries/Chromium.cmake
@@ -0,0 +1,17 @@
+if (DEP_MSAN_ORIGIN_TRACKING)
+    set(chromium_url https://www.googleapis.com/download/storage/v1/b/chromium-browser-msan/o/linux-release%2Fmsan-chained-origins-linux-release-812431.zip?alt=media)
+    set(chromium_url_hash b99c3e50ab936e44f6e5b4e28b7f8bab0b01912bcb068af258f366fe1e18a6f6)
+else ()
+    set(chromium_url https://www.googleapis.com/download/storage/v1/b/chromium-browser-msan/o/linux-release%2Fmsan-no-origins-linux-release-812433.zip?alt=media)
+    set(chromium_url_hash cfacfe4c2c3ee284015b74ada493cb992d4f7ac82e6325d27384d18437738c4c)
+endif ()
+
+ExternalProject_Add(dep_Chromium_Libs
+        URL ${chromium_url}
+        URL_HASH SHA256=${chromium_url_hash}
+        DOWNLOAD_DIR ${DEP_DOWNLOAD_DIR}/Chromium_Libs
+        BUILD_IN_SOURCE ON
+        CONFIGURE_COMMAND ""
+        BUILD_COMMAND ""
+        INSTALL_COMMAND ${CMAKE_COMMAND} "-D_MSAN_COPY_FROM=./instrumented_libraries_prebuilt/msan/lib" "-D_MSAN_COPY_TO=${DESTDIR}/usr/lib" -P ${CMAKE_CURRENT_LIST_DIR}/copy_chromium_prebuilt_libraries.cmake
+        )
diff --git a/deps/MSan_Deps/Chromium_prebuilt_libraries/copy_chromium_prebuilt_libraries.cmake b/deps/MSan_Deps/Chromium_prebuilt_libraries/copy_chromium_prebuilt_libraries.cmake
new file mode 100644
index 0000000000..927ef72c8b
--- /dev/null
+++ b/deps/MSan_Deps/Chromium_prebuilt_libraries/copy_chromium_prebuilt_libraries.cmake
@@ -0,0 +1,86 @@
+function(copy_chromium_prebuilt_libraries path_from path_to)
+    if (NOT ${ARGC} EQUAL 2)
+        message(FATAL_ERROR "Invalid argument count.")
+    endif()
+
+    set(chromium_libs_list
+            libatk-1.0
+            libatk-bridge-2.0
+            libatspi
+            libcairo
+            libcairo-gobject
+            libcairo-script-interpreter
+            libdbus-1
+            libdbus-glib-1
+            libdbusmenu-glib
+            libdbusmenu-gtk
+            libdbusmenu-gtk3
+            libdbusmenu-jsonloader
+            libffi
+            libfreetype
+            libgdk-3
+            libgdk_pixbuf-2.0
+            libgdk_pixbuf_xlib-2.0
+            libgio-2.0
+            libglib-2.0
+            libgobject-2.0
+            libgtk-3
+            libharfbuzz
+            libharfbuzz-gobject
+            libharfbuzz-icu
+            libjasper
+            libpango-1.0
+            libpangocairo-1.0
+            libpangoft2-1.0
+            libpangoxft-1.0
+            libpixman-1
+            libpng12
+            libsecret-1
+            libudev
+            libX11
+            libX11-xcb
+            libXau
+            libxcb
+            libXcomposite
+            libXcursor
+            libXdamage
+            libXdmcp
+            libXext
+            libXfixes
+            libXinerama
+            libXi
+            libXrandr
+            libXrender
+            libXss
+            libXtst)
+
+    set(chromium_libs_dirs_list
+            cairo
+            dbus-1.0
+            glib-2.0
+            gtk-2.0
+            gtk-3.0
+            udev)
+
+    foreach(chromium_lib ${chromium_libs_list})
+        file(GLOB chromium_lib_files "${path_from}/${chromium_lib}*")
+        if (NOT chromium_lib_files)
+            message(FATAL_ERROR "Library \"${chromium_lib}\" was not found.")
+        endif()
+        foreach(chromium_lib_file ${chromium_lib_files})
+            file(COPY ${chromium_lib_file} DESTINATION ${path_to})
+            message("Copying file: ${chromium_lib_file}.")
+        endforeach()
+    endforeach()
+
+    foreach(chromium_lib_dir ${chromium_libs_dirs_list})
+        file(GLOB lib_directory "${path_from}/${chromium_lib_dir}")
+        if (NOT lib_directory)
+            message(FATAL_ERROR "Library directory \"${chromium_lib_dir}\" was not found.")
+        endif()
+        file(COPY ${lib_directory} DESTINATION ${path_to})
+        message("Copying directory: ${lib_directory}.")
+    endforeach()
+endfunction()
+
+copy_chromium_prebuilt_libraries(${_MSAN_COPY_FROM} ${_MSAN_COPY_TO})
diff --git a/deps/MSan_Deps/LLVM/LLVM.cmake b/deps/MSan_Deps/LLVM/LLVM.cmake
new file mode 100644
index 0000000000..79576e5850
--- /dev/null
+++ b/deps/MSan_Deps/LLVM/LLVM.cmake
@@ -0,0 +1,54 @@
+set(projectname LLVM)
+
+set(_llvm_cmake_c_flags             "-fPIC")
+set(_llvm_cmake_cxx_flags           "-nostdinc++ -isystem ${DESTDIR}/usr/local/include -isystem ${DESTDIR}/usr/local/include/c++/v1 -fPIC")
+set(_llvm_cmake_exe_linker_flags    "-stdlib=libc++ -Wl,--rpath=${DESTDIR}/usr/local/lib -L${DESTDIR}/usr/local/lib -fsanitize=memory -fPIC")
+set(_llvm_cmake_shared_linker_flags "-stdlib=libc++ -Wl,--rpath=${DESTDIR}/usr/local/lib -L${DESTDIR}/usr/local/lib -fsanitize=memory -fPIC")
+set(_llvm_cmake_module_linker_flags "-stdlib=libc++ -Wl,--rpath=${DESTDIR}/usr/local/lib -L${DESTDIR}/usr/local/lib -fsanitize=memory -fPIC")
+
+# TODO: Build LLVM statically and link with Mesa 3D.
+
+ExternalProject_Add(dep_LLVM
+        URL https://github.com/llvm/llvm-project/releases/download/llvmorg-12.0.1/llvm-project-12.0.1.src.tar.xz
+        URL_HASH SHA256=129cb25cd13677aad951ce5c2deb0fe4afc1e9d98950f53b51bdcfb5a73afa0e
+        DEPENDS dep_Libcxx
+        EXCLUDE_FROM_ALL ON
+        INSTALL_DIR      ${DESTDIR}/usr/local
+        DOWNLOAD_DIR     ${DEP_DOWNLOAD_DIR}/LLVM
+        LIST_SEPARATOR   | # Use the alternate list separator because by default all ; are replaced by space
+        CMAKE_ARGS
+            -DCMAKE_INSTALL_PREFIX:STRING=${DESTDIR}/usr/local
+            -DCMAKE_MODULE_PATH:STRING=${PROJECT_SOURCE_DIR}/../cmake/modules
+            -DCMAKE_PREFIX_PATH:STRING=${DESTDIR}/usr/local
+            -DCMAKE_C_COMPILER:STRING=${CMAKE_C_COMPILER}
+            -DCMAKE_CXX_COMPILER:STRING=${CMAKE_CXX_COMPILER}
+            -DCMAKE_TOOLCHAIN_FILE:STRING=${CMAKE_TOOLCHAIN_FILE}
+
+        -DCMAKE_BUILD_TYPE=Release
+        -DLLVM_USE_SANITIZER=MemoryWithOrigins
+        #        -DLLVM_ENABLE_PROJECTS=clang|lld|llvm-config
+        -DLLVM_ENABLE_PROJECTS=LLVM|llvm-config
+        -DLLVM_ENABLE_LIBCXX=ON
+
+         # This forces to make shared library.
+        -DLLVM_BUILD_LLVM_DYLIB=ON
+        -DLLVM_LINK_LLVM_DYLIB=ON
+        -DLLVM_DYLIB_COMPONENTS=all
+
+        #        -DLLVM_TARGETS_TO_BUILD=X86
+        -DLLVM_ENABLE_PIC=ON
+
+
+        -DCMAKE_C_FLAGS:STRING=${_llvm_cmake_c_flags}
+        -DCMAKE_CXX_FLAGS:STRING=${_llvm_cmake_cxx_flags}
+        -DCMAKE_EXE_LINKER_FLAGS:STRING=${_llvm_cmake_exe_linker_flags}
+        -DCMAKE_SHARED_LINKER_FLAGS:STRING=${_llvm_cmake_shared_linker_flags}
+        -DCMAKE_MODULE_LINKER_FLAGS:STRING=${_llvm_cmake_module_linker_flags}
+
+        SOURCE_SUBDIR llvm
+        BUILD_COMMAND ${CMAKE_COMMAND} --build . --config Release --target LLVM llvm-config -- ${_build_j}
+        INSTALL_COMMAND ${CMAKE_COMMAND} --build . --config Release --target install-LLVM install-llvm-config install-llvm-headers
+            COMMAND ln -sfn "../local/lib/libLLVM.so" "${DESTDIR}/usr/lib/libLLVM.so"
+            COMMAND ln -sfn "../local/lib/libLLVM-12.so" "${DESTDIR}/usr/lib/libLLVM-12.so"
+            COMMAND ln -sfn "../local/lib/libLLVM-12.0.1.so" "${DESTDIR}/usr/lib/libLLVM-12.0.1.so"
+        )
diff --git a/deps/MSan_Deps/Libcxx/Libcxx.cmake b/deps/MSan_Deps/Libcxx/Libcxx.cmake
new file mode 100644
index 0000000000..a00720a7ef
--- /dev/null
+++ b/deps/MSan_Deps/Libcxx/Libcxx.cmake
@@ -0,0 +1,28 @@
+set(_build_j "-j${NPROC}")
+ExternalProject_Add(dep_Libcxx
+        URL https://github.com/llvm/llvm-project/releases/download/llvmorg-12.0.1/llvm-project-12.0.1.src.tar.xz
+        URL_HASH SHA256=129cb25cd13677aad951ce5c2deb0fe4afc1e9d98950f53b51bdcfb5a73afa0e
+        EXCLUDE_FROM_ALL ON
+        INSTALL_DIR      ${DESTDIR}/usr/local
+        DOWNLOAD_DIR     ${DEP_DOWNLOAD_DIR}/Libcxx
+        LIST_SEPARATOR   | # Use the alternate list separator because by default all ; are replaced by space
+        CMAKE_ARGS
+            -DCMAKE_INSTALL_PREFIX:STRING=${DESTDIR}/usr/local
+            -DCMAKE_MODULE_PATH:STRING=${PROJECT_SOURCE_DIR}/../cmake/modules
+            -DCMAKE_PREFIX_PATH:STRING=${DESTDIR}/usr/local
+            -DCMAKE_C_COMPILER:STRING=${CMAKE_C_COMPILER}
+            -DCMAKE_CXX_COMPILER:STRING=${CMAKE_CXX_COMPILER}
+            -DCMAKE_TOOLCHAIN_FILE:STRING=${CMAKE_TOOLCHAIN_FILE}
+            -DCMAKE_BUILD_TYPE=Release
+            -DLLVM_ENABLE_PROJECTS=libcxx|libcxxabi
+            -DLLVM_USE_SANITIZER=MemoryWithOrigins
+        SOURCE_SUBDIR llvm
+        BUILD_COMMAND ${CMAKE_COMMAND} --build . --config Release --target cxx cxxabi -- ${_build_j}
+        INSTALL_COMMAND ${CMAKE_COMMAND} --build . --config Release --target install-cxx install-cxxabi
+            COMMAND     ln -sfn "../local/lib/libc++.so" "${DESTDIR}/usr/lib/libc++.so"
+            COMMAND     ln -sfn "../local/lib/libc++.so.1" "${DESTDIR}/usr/lib/libc++.so.1"
+            COMMAND     ln -sfn "../local/lib/libc++.so.1.0" "${DESTDIR}/usr/lib/libc++.so.1.0"
+            COMMAND     ln -sfn "../local/lib/libc++abi.so" "${DESTDIR}/usr/lib/libc++abi.so"
+            COMMAND     ln -sfn "../local/lib/libc++abi.so.1" "${DESTDIR}/usr/lib/libc++abi.so.1"
+            COMMAND     ln -sfn "../local/lib/libc++abi.so.1.0" "${DESTDIR}/usr/lib/libc++abi.so.1.0"
+)
diff --git a/deps/MSan_Deps/Mesa3D/Mesa3D.cmake b/deps/MSan_Deps/Mesa3D/Mesa3D.cmake
new file mode 100644
index 0000000000..9fa35acb43
--- /dev/null
+++ b/deps/MSan_Deps/Mesa3D/Mesa3D.cmake
@@ -0,0 +1,19 @@
+set(_mesa3d_cflags "-fsanitize=memory -stdlib=libc++ -fsanitize-recover=memory -fsanitize-blacklist=${CMAKE_CURRENT_LIST_DIR}/ignorelist.txt -I${DESTDIR}/usr/local/include -I${DESTDIR}/usr/local/include/c++/v1")
+set(_mesa3d_cxxflags "-fsanitize=memory -stdlib=libc++ -fsanitize-recover=memory -fsanitize-blacklist=${CMAKE_CURRENT_LIST_DIR}/ignorelist.txt -I${DESTDIR}/usr/local/include -I${DESTDIR}/usr/local/include/c++/v1")
+set(_mesa3d_ldflags "-fsanitize=memory -stdlib=libc++ -fsanitize-recover=memory -fsanitize-blacklist=${CMAKE_CURRENT_LIST_DIR}/ignorelist.txt -L${DESTDIR}/usr/local/lib -Wl,-rpath,${DESTDIR}/usr/local/lib")
+set(_mesa3d_path "${DESTDIR}/usr/local/bin:$ENV{PATH}")
+
+# We need to override PATH variable to make Meson find our build llvm-config and not use system one.
+
+ExternalProject_Add(dep_Mesa3D
+        URL https://archive.mesa3d.org/mesa-21.3.3.tar.xz
+        URL_HASH SHA256=ad7f4613ea7c5d08d9fcb5025270199e6ceb9aa99fd72ee572b70342240a8121
+        DEPENDS dep_Libcxx dep_LLVM dep_Chromium_Libs
+        DOWNLOAD_DIR ${DEP_DOWNLOAD_DIR}/Mesa3D
+        BUILD_IN_SOURCE ON
+        CONFIGURE_COMMAND env "PATH=${_mesa3d_path}" "CFLAGS=${_mesa3d_cflags}" "CXXFLAGS=${_mesa3d_cxxflags}" "LDFLAGS=${_mesa3d_ldflags}" meson build_mesa -Dglx=gallium-xlib -Dgallium-drivers=swrast -Dplatforms=x11 -Ddri3=disabled "-Ddri-drivers=" "-Dvulkan-drivers=" -Db_sanitize=memory -Db_lundef=false -Dgles1=disabled -Dgles2=disabled -Dshared-glapi=disabled "-Dprefix=${DESTDIR}/usr/local" "-Dlibdir=${DESTDIR}/usr/local/lib"
+        BUILD_COMMAND     ninja -C build_mesa install
+        INSTALL_COMMAND   ln -sfn "../local/lib/libGL.so" "${DESTDIR}/usr/lib/libGL.so"
+            COMMAND       ln -sfn "../local/lib/libGL.so.1" "${DESTDIR}/usr/lib/libGL.so.1"
+            COMMAND       ln -sfn "../local/lib/libGL.so.1.5.0" "${DESTDIR}/usr/lib/libGL.so.1.5.0"
+)
\ No newline at end of file
diff --git a/deps/MSan_Deps/Mesa3D/ignorelist.txt b/deps/MSan_Deps/Mesa3D/ignorelist.txt
new file mode 100644
index 0000000000..342b421199
--- /dev/null
+++ b/deps/MSan_Deps/Mesa3D/ignorelist.txt
@@ -0,0 +1,55 @@
+fun:single_output_color
+fun:flush_spans
+fun:subtriangle
+fun:sp_setup_tri
+fun:sp_vbuf_draw_arrays
+fun:draw_pt_emit_linear
+fun:emit
+fun:fetch_pipeline_generic
+fun:fetch_pipeline_linear_run
+fun:vsplit_run_linear
+fun:draw_pt_arrays
+fun:draw_instances
+fun:draw_vbo
+fun:softpipe_draw_vbo
+fun:_mesa_draw_arrays
+fun:_mesa_DrawArrays
+fun:setup_sort_vertices
+fun:setup_tri_edges
+fun:sp_setup_tri
+fun:sp_vbuf_draw_arrays
+fun:util_set_thread_affinity
+fun:clamp_colors
+fun:exec_run
+fun:shade_quad
+fun:shade_quads
+fun:depth_test_quads_fallback
+fun:blend_single_add_src_alpha_inv_src_alpha
+fun:tgsi_exec_machine_setup_masks
+fun:tgsi_exec_machine_run
+fun:depth_test_quad
+fun:util_format_r8g8b8a8_unorm_unpack_rgba_float
+fun:sp_get_cached_tile_tex
+fun:get_texel_2d
+fun:sp_find_cached_tile_tex
+fun:sp_get_cached_tile_tex
+fun:compute_lambda_lod
+fun:util_fast_log2
+fun:img_filter_2d_linear
+fun:sp_get_cache
+fun:util_copy_rect
+fun:util_format_unpack_rgba_rect
+fun:u_clip_tile
+fun:img_filter_2d_linear_repeat_POT
+fun:micro_div
+fun:img_filter_2d_ewa
+fun:convert_quad_depth
+fun:calc_fixed_position
+fun:try_setup_line
+fun:setup_fragcoord_coef
+fun:clip_tri
+fun:do_clip_tri
+fun:emit_vertex
+fun:cull_tri
+fun:clip_line
+fun:do_clip_line
\ No newline at end of file
diff --git a/deps/MSan_Deps/fontconfig/fontconfig.cmake b/deps/MSan_Deps/fontconfig/fontconfig.cmake
new file mode 100644
index 0000000000..73f2ccafa2
--- /dev/null
+++ b/deps/MSan_Deps/fontconfig/fontconfig.cmake
@@ -0,0 +1,16 @@
+set(_fontconfig_cflags "-fsanitize=memory -stdlib=libc++ -fsanitize-recover=memory -I${DESTDIR}/usr/local/include -I${DESTDIR}/usr/local/include/c++/v1")
+set(_fontconfig_cxxflags "-fsanitize=memory -stdlib=libc++ -fsanitize-recover=memory -I${DESTDIR}/usr/local/include -I${DESTDIR}/usr/local/include/c++/v1")
+set(_fontconfig_ldflags "-fsanitize=memory -stdlib=libc++ -fsanitize-recover=memory -L${DESTDIR}/usr/local/lib -Wl,-rpath,${DESTDIR}/usr/local/lib")
+
+ExternalProject_Add(dep_fontconfig
+        URL https://www.freedesktop.org/software/fontconfig/release/fontconfig-2.13.1.tar.gz
+        URL_HASH SHA256=9f0d852b39d75fc655f9f53850eb32555394f36104a044bb2b2fc9e66dbbfa7f
+        DEPENDS dep_Libcxx
+        DOWNLOAD_DIR ${DEP_DOWNLOAD_DIR}/fontconfig
+        BUILD_IN_SOURCE ON
+        CONFIGURE_COMMAND  env "CFLAGS=${_fontconfig_cflags}" "CXXFLAGS=${_fontconfig_cxxflags}" "LDFLAGS=${_fontconfig_ldflags}" ./configure --disable-docs --disable-static "--sysconfdir=/etc" "--localstatedir=/var" "--prefix=${DESTDIR}/usr/local"
+        INSTALL_COMMAND make install-exec && cd fontconfig && make install-fontconfigincludeHEADERS
+            COMMAND     ln -sfn "../local/lib/libfontconfig.so" "${DESTDIR}/usr/lib/libfontconfig.so"
+            COMMAND     ln -sfn "../local/lib/libfontconfig.so.1" "${DESTDIR}/usr/lib/libfontconfig.so.1"
+            COMMAND     ln -sfn "../local/lib/libfontconfig.so.1.12.0" "${DESTDIR}/usr/lib/libfontconfig.so.1.12.0"
+        )
diff --git a/deps/MSan_Deps/install_msan_shared_libraries.cmake b/deps/MSan_Deps/install_msan_shared_libraries.cmake
new file mode 100644
index 0000000000..7b47a9a9d2
--- /dev/null
+++ b/deps/MSan_Deps/install_msan_shared_libraries.cmake
@@ -0,0 +1,34 @@
+function(install_msan_shared_libraries path_from path_to)
+    if (NOT ${ARGC} EQUAL 2)
+        message(FATAL_ERROR "Invalid argument count.")
+    endif()
+
+    set(msan_libs_list
+            libc++
+            libc++abi
+            libfontconfig
+            libGL
+            libLLVM)
+
+    foreach(msan_lib ${msan_libs_list})
+        file(GLOB msan_lib_files "${path_from}/${msan_lib}*")
+        if (NOT msan_lib_files)
+            message(FATAL_ERROR "Library \"${msan_lib}\" was not found.")
+        endif()
+        foreach(msan_lib_file ${msan_lib_files})
+            file(COPY ${msan_lib_file} DESTINATION ${path_to})
+            message("Copying file: ${msan_lib_file}.")
+        endforeach()
+    endforeach()
+
+    foreach(msan_lib_dir ${msan_libs_dirs_list})
+        file(GLOB lib_directory "${path_from}/${msan_lib_dir}")
+        if (NOT lib_directory)
+            message(FATAL_ERROR "Library directory \"${msan_lib_dir}\" was not found.")
+        endif()
+        file(COPY ${lib_directory} DESTINATION ${path_to})
+        message("Copying directory: ${lib_directory}.")
+    endforeach()
+endfunction()
+
+install_msan_shared_libraries(${_MSAN_COPY_FROM} ${_MSAN_COPY_TO})
diff --git a/deps/NLopt/NLopt.cmake b/deps/NLopt/NLopt.cmake
index db638c8971..e2985a1208 100644
--- a/deps/NLopt/NLopt.cmake
+++ b/deps/NLopt/NLopt.cmake
@@ -1,6 +1,7 @@
 prusaslicer_add_cmake_project(NLopt
   URL "https://github.com/stevengj/nlopt/archive/v2.5.0.tar.gz"
   URL_HASH SHA256=c6dd7a5701fff8ad5ebb45a3dc8e757e61d52658de3918e38bab233e7fd3b4ae
+  DEPENDS ${LIBCXX_PKG}
   CMAKE_ARGS
     -DNLOPT_PYTHON:BOOL=OFF
     -DNLOPT_OCTAVE:BOOL=OFF
@@ -8,6 +9,7 @@ prusaslicer_add_cmake_project(NLopt
     -DNLOPT_GUILE:BOOL=OFF
     -DNLOPT_SWIG:BOOL=OFF
     -DNLOPT_TESTS:BOOL=OFF
+    ${MSAN_CMAKE_ARGS}
 )
 
 if (MSVC)
diff --git a/deps/OpenCSG/OpenCSG.cmake b/deps/OpenCSG/OpenCSG.cmake
index 4d980fecd1..659889c533 100644
--- a/deps/OpenCSG/OpenCSG.cmake
+++ b/deps/OpenCSG/OpenCSG.cmake
@@ -5,7 +5,9 @@ prusaslicer_add_cmake_project(OpenCSG
     URL https://github.com/floriankirsch/OpenCSG/archive/refs/tags/opencsg-1-4-2-release.zip
     URL_HASH SHA256=51afe0db79af8386e2027d56d685177135581e0ee82ade9d7f2caff8deab5ec5
     PATCH_COMMAND ${CMAKE_COMMAND} -E copy ${CMAKE_CURRENT_LIST_DIR}/CMakeLists.txt.in ./CMakeLists.txt
-    DEPENDS dep_GLEW
+    DEPENDS ${LIBCXX_PKG} dep_GLEW
+    CMAKE_ARGS
+        ${MSAN_CMAKE_ARGS}
 )
 
 if (TARGET ${ZLIB_PKG})
diff --git a/deps/OpenEXR/OpenEXR.cmake b/deps/OpenEXR/OpenEXR.cmake
index 046223fed9..74e93fa4c5 100644
--- a/deps/OpenEXR/OpenEXR.cmake
+++ b/deps/OpenEXR/OpenEXR.cmake
@@ -2,7 +2,7 @@ prusaslicer_add_cmake_project(OpenEXR
     # GIT_REPOSITORY https://github.com/openexr/openexr.git
     URL https://github.com/AcademySoftwareFoundation/openexr/archive/refs/tags/v2.5.5.zip
     URL_HASH SHA256=0307a3d7e1fa1e77e9d84d7e9a8694583fbbbfd50bdc6884e2c96b8ef6b902de
-    DEPENDS ${ZLIB_PKG}
+    DEPENDS ${LIBCXX_PKG} ${ZLIB_PKG}
     GIT_TAG v2.5.5
     CMAKE_ARGS
         -DCMAKE_POSITION_INDEPENDENT_CODE=ON
@@ -10,6 +10,7 @@ prusaslicer_add_cmake_project(OpenEXR
         -DPYILMBASE_ENABLE:BOOL=OFF 
         -DOPENEXR_VIEWERS_ENABLE:BOOL=OFF
         -DOPENEXR_BUILD_UTILS:BOOL=OFF
+        ${MSAN_CMAKE_ARGS}
 )
 
 if (MSVC)
diff --git a/deps/OpenSSL/OpenSSL.cmake b/deps/OpenSSL/OpenSSL.cmake
index 347b30d056..7543b91759 100644
--- a/deps/OpenSSL/OpenSSL.cmake
+++ b/deps/OpenSSL/OpenSSL.cmake
@@ -21,6 +21,7 @@ ExternalProject_Add(dep_OpenSSL
     EXCLUDE_FROM_ALL ON
     URL "https://github.com/openssl/openssl/archive/OpenSSL_1_1_0l.tar.gz"
     URL_HASH SHA256=e2acf0cf58d9bff2b42f2dc0aee79340c8ffe2c5e45d3ca4533dd5d4f5775b1d
+    DEPENDS ${LIBCXX_PKG}
     DOWNLOAD_DIR ${DEP_DOWNLOAD_DIR}/OpenSSL
     BUILD_IN_SOURCE ON
     CONFIGURE_COMMAND ${_conf_cmd} ${_cross_arch}
@@ -30,6 +31,8 @@ ExternalProject_Add(dep_OpenSSL
         no-ssl3-method
         no-dynamic-engine
         -Wa,--noexecstack
+        "${MSAN_CMAKE_C_FLAGS}"
+        "${MSAN_CMAKE_LD_FLAGS}"
     BUILD_COMMAND make depend && make "-j${NPROC}"
     INSTALL_COMMAND make install_sw
 )
\ No newline at end of file
diff --git a/deps/OpenVDB/OpenVDB.cmake b/deps/OpenVDB/OpenVDB.cmake
index 10dc2d916f..86149d07a6 100644
--- a/deps/OpenVDB/OpenVDB.cmake
+++ b/deps/OpenVDB/OpenVDB.cmake
@@ -8,8 +8,8 @@ endif()
 
 prusaslicer_add_cmake_project(OpenVDB
     URL https://github.com/tamasmeszaros/openvdb/archive/refs/tags/v6.2.1-prusa3d.zip #v6.2.1 patched
-    URL_HASH SHA256=caf9f0c91976722883ff9cb32420ef142af22f7e625fc643b91c23d6e4172f62 
-    DEPENDS dep_TBB dep_Blosc dep_OpenEXR dep_Boost
+    URL_HASH SHA256=caf9f0c91976722883ff9cb32420ef142af22f7e625fc643b91c23d6e4172f62
+    DEPENDS ${LIBCXX_PKG} dep_TBB dep_Blosc dep_OpenEXR dep_Boost
     CMAKE_ARGS
         -DCMAKE_POSITION_INDEPENDENT_CODE=ON 
         -DOPENVDB_BUILD_PYTHON_MODULE=OFF
@@ -20,6 +20,7 @@ prusaslicer_add_cmake_project(OpenVDB
         -DTBB_STATIC=${_build_static}
         -DOPENVDB_BUILD_VDB_PRINT=ON
         -DDISABLE_DEPENDENCY_VERSION_CHECKS=ON # Centos6 has old zlib
+        ${MSAN_CMAKE_ARGS}
 )
 
 if (MSVC)
diff --git a/deps/PNG/PNG.cmake b/deps/PNG/PNG.cmake
index f97ebb4e08..3d5711bd89 100644
--- a/deps/PNG/PNG.cmake
+++ b/deps/PNG/PNG.cmake
@@ -10,19 +10,24 @@ if (APPLE)
     set(_patch_step PATCH_COMMAND ${PATCH_CMD} ${CMAKE_CURRENT_LIST_DIR}/PNG.patch)
 endif ()
 
+if (NOT DEP_MSAN)
+    set(_png_prefix -DPNG_PREFIX=prusaslicer_)
+endif ()
+
 prusaslicer_add_cmake_project(PNG 
     # GIT_REPOSITORY https://github.com/glennrp/libpng.git 
     # GIT_TAG v1.6.35
     URL https://github.com/glennrp/libpng/archive/refs/tags/v1.6.35.zip
     URL_HASH SHA256=3d22d46c566b1761a0e15ea397589b3a5f36ac09b7c785382e6470156c04247f
-    DEPENDS ${ZLIB_PKG}
+    DEPENDS ${LIBCXX_PKG} ${ZLIB_PKG}
     "${_patch_step}"
     CMAKE_ARGS
         -DPNG_SHARED=OFF
         -DPNG_STATIC=ON
-        -DPNG_PREFIX=prusaslicer_
+        ${_png_prefix}
         -DPNG_TESTS=OFF
         -DDISABLE_DEPENDENCY_TRACKING=OFF
+        ${MSAN_CMAKE_ARGS}
         ${_disable_neon_extension}
 )
 
diff --git a/deps/Qhull/Qhull.cmake b/deps/Qhull/Qhull.cmake
index fedec550c1..77f437ed24 100644
--- a/deps/Qhull/Qhull.cmake
+++ b/deps/Qhull/Qhull.cmake
@@ -2,8 +2,10 @@ include(GNUInstallDirs)
 prusaslicer_add_cmake_project(Qhull
     URL "https://github.com/qhull/qhull/archive/v8.0.1.zip"
     URL_HASH SHA256=5287f5edd6a0372588f5d6640799086a4033d89d19711023ef8229dd9301d69b
+    DEPENDS ${LIBCXX_PKG}
     CMAKE_ARGS 
         -DINCLUDE_INSTALL_DIR=${CMAKE_INSTALL_INCLUDEDIR}
+        ${MSAN_CMAKE_ARGS}
 )
 
 if (MSVC)
diff --git a/deps/TBB/TBB.cmake b/deps/TBB/TBB.cmake
index 7315716e0b..b730f5ff5a 100644
--- a/deps/TBB/TBB.cmake
+++ b/deps/TBB/TBB.cmake
@@ -2,12 +2,14 @@ prusaslicer_add_cmake_project(
     TBB
     URL "https://github.com/wjakob/tbb/archive/a0dc9bf76d0120f917b641ed095360448cabc85b.tar.gz"
     URL_HASH SHA256=0545cb6033bd1873fcae3ea304def720a380a88292726943ae3b9b207f322efe
+    DEPENDS ${LIBCXX_PKG}
     CMAKE_ARGS          
         -DTBB_BUILD_SHARED=OFF
         -DTBB_BUILD_TESTS=OFF
         -DTBB_BUILD_TESTS=OFF
         -DCMAKE_POSITION_INDEPENDENT_CODE=ON
         -DCMAKE_DEBUG_POSTFIX=_debug
+        ${MSAN_CMAKE_ARGS}
 )
 
 if (MSVC)
diff --git a/deps/TIFF/TIFF.cmake b/deps/TIFF/TIFF.cmake
index f92dd08110..c66f5a5464 100644
--- a/deps/TIFF/TIFF.cmake
+++ b/deps/TIFF/TIFF.cmake
@@ -3,11 +3,12 @@ find_package(OpenGL QUIET REQUIRED)
 prusaslicer_add_cmake_project(TIFF
     URL https://gitlab.com/libtiff/libtiff/-/archive/v4.1.0/libtiff-v4.1.0.zip
     URL_HASH SHA256=c56edfacef0a60c0de3e6489194fcb2f24c03dbb550a8a7de5938642d045bd32
-    DEPENDS ${ZLIB_PKG} ${PNG_PKG} dep_JPEG
+    DEPENDS ${LIBCXX_PKG} ${ZLIB_PKG} ${PNG_PKG} dep_JPEG
     CMAKE_ARGS
         -Dlzma:BOOL=OFF
         -Dwebp:BOOL=OFF
         -Djbig:BOOL=OFF
         -Dzstd:BOOL=OFF
         -Dpixarlog:BOOL=OFF
+        ${MSAN_CMAKE_ARGS}
 )
diff --git a/deps/ZLIB/ZLIB.cmake b/deps/ZLIB/ZLIB.cmake
index 916f3318ba..2bf8c5b9c1 100644
--- a/deps/ZLIB/ZLIB.cmake
+++ b/deps/ZLIB/ZLIB.cmake
@@ -3,9 +3,11 @@ prusaslicer_add_cmake_project(ZLIB
   # GIT_TAG v1.2.11
   URL https://github.com/madler/zlib/archive/refs/tags/v1.2.11.zip
   URL_HASH SHA256=f5cc4ab910db99b2bdbba39ebbdc225ffc2aa04b4057bc2817f1b94b6978cfc3
+  DEPENDS ${LIBCXX_PKG}
   PATCH_COMMAND ${PATCH_CMD} ${CMAKE_CURRENT_LIST_DIR}/0001-Respect-BUILD_SHARED_LIBS.patch
   CMAKE_ARGS
     -DSKIP_INSTALL_FILES=ON         # Prevent installation of man pages et al.
     -DCMAKE_POSITION_INDEPENDENT_CODE=ON
+    ${MSAN_CMAKE_ARGS}
 )
 
diff --git a/deps/wxWidgets/wxWidgets.cmake b/deps/wxWidgets/wxWidgets.cmake
index c8051e21f9..eb40a5bd3d 100644
--- a/deps/wxWidgets/wxWidgets.cmake
+++ b/deps/wxWidgets/wxWidgets.cmake
@@ -9,12 +9,48 @@ if(CMAKE_SYSTEM_NAME STREQUAL "Linux")
     set(_wx_toolkit "-DwxBUILD_TOOLKIT=gtk${_gtk_ver}")
 endif()
 
+set(_wx_config_command "")
+if (DEP_MSAN)
+    set(_wx_cmake_args
+            -DCMAKE_INSTALL_PREFIX:STRING=${DESTDIR}/usr/local
+            -DCMAKE_MODULE_PATH:STRING=${PROJECT_SOURCE_DIR}/../cmake/modules
+            -DCMAKE_PREFIX_PATH:STRING=${DESTDIR}/usr/local
+            -DCMAKE_DEBUG_POSTFIX:STRING=d
+            -DCMAKE_C_COMPILER:STRING=${CMAKE_C_COMPILER}
+            -DCMAKE_CXX_COMPILER:STRING=${CMAKE_CXX_COMPILER}
+            -DCMAKE_TOOLCHAIN_FILE:STRING=${CMAKE_TOOLCHAIN_FILE}
+            -DBUILD_SHARED_LIBS:BOOL=OFF
+            -DCMAKE_BUILD_TYPE:STRING=${CMAKE_BUILD_TYPE}
+            ${DEP_CMAKE_OPTS}
+            -DwxBUILD_PRECOMP=ON
+            ${_wx_toolkit}
+            "-DCMAKE_DEBUG_POSTFIX:STRING="
+            -DwxBUILD_DEBUG_LEVEL=0
+            -DwxUSE_MEDIACTRL=OFF
+            -DwxUSE_DETECT_SM=OFF
+            -DwxUSE_UNICODE=ON
+            -DwxUSE_OPENGL=ON
+            -DwxUSE_LIBPNG=sys
+            -DwxUSE_ZLIB=sys
+            -DwxUSE_REGEX=builtin
+            -DwxUSE_LIBXPM=builtin
+            -DwxUSE_LIBJPEG=sys
+            -DwxUSE_LIBTIFF=sys
+            -DwxUSE_EXPAT=sys
+            -DwxUSE_LIBSDL=OFF
+            -DwxUSE_XTEST=OFF)
+    set(_wx_config_command CONFIGURE_COMMAND ${CMAKE_COMMAND} -E env "CFLAGS=${MSAN_CMAKE_C_FLAGS}" "CXXFLAGS=${MSAN_CMAKE_CXX_FLAGS}" "LDFLAGS=${MSAN_CMAKE_LD_FLAGS}" ${CMAKE_COMMAND}
+            ${_wx_cmake_args}
+            "${CMAKE_GENERATOR}"
+            ${DEP_DOWNLOAD_DIR}/dep_wxWidgets-prefix/src/dep_wxWidgets)
+endif ()
+
 prusaslicer_add_cmake_project(wxWidgets
     # GIT_REPOSITORY "https://github.com/prusa3d/wxWidgets"
     # GIT_TAG tm_cross_compile #${_wx_git_tag}
     URL https://github.com/prusa3d/wxWidgets/archive/refs/heads/v3.1.4-patched.zip
     URL_HASH SHA256=69dec874981d2fc3d90345660c27f3450d8430c483e8446edcc87b6ed18bff8f
-    DEPENDS ${PNG_PKG} ${ZLIB_PKG} ${EXPAT_PKG} dep_TIFF dep_JPEG
+    DEPENDS ${LIBCXX_PKG} ${FONTCONFIG_PKG} ${PNG_PKG} ${ZLIB_PKG} ${EXPAT_PKG} dep_TIFF dep_JPEG
     CMAKE_ARGS
         -DwxBUILD_PRECOMP=ON
         ${_wx_toolkit}
@@ -33,6 +69,7 @@ prusaslicer_add_cmake_project(wxWidgets
         -DwxUSE_EXPAT=sys
         -DwxUSE_LIBSDL=OFF
         -DwxUSE_XTEST=OFF
+    ${_wx_config_command}
 )
 
 if (MSVC)
diff --git a/src/CMakeLists.txt b/src/CMakeLists.txt
index 9e89e82f67..920aeee2f4 100644
--- a/src/CMakeLists.txt
+++ b/src/CMakeLists.txt
@@ -251,9 +251,15 @@ else ()
         set(BIN_RESOURCES_DIR "${CMAKE_CURRENT_BINARY_DIR}/../resources")
     endif ()
     add_custom_command(TARGET PrusaSlicer POST_BUILD
-        COMMAND ln -sfn "${SLIC3R_RESOURCES_DIR}" "${BIN_RESOURCES_DIR}"
-        COMMENT "Symlinking the resources directory into the build tree"
-        VERBATIM)
+            COMMAND ln -sfn "${SLIC3R_RESOURCES_DIR}" "${BIN_RESOURCES_DIR}"
+            COMMENT "Symlinking the resources directory into the build tree"
+            VERBATIM)
+    if (SLIC3R_MSAN)
+        add_custom_command(TARGET PrusaSlicer POST_BUILD
+                COMMAND ln -sfn "${CMAKE_PREFIX_PATH}/../lib" "${CMAKE_CURRENT_BINARY_DIR}/../lib"
+                COMMENT "Symlinking the instrument library directory into the build tree"
+                VERBATIM)
+    endif ()
 endif ()
 
 # Slic3r binary install target